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Project Information: Enter the proposed end date.
Research Area: Choose one research area from the list that best describes the proposed work.
Cancer Site Addressed: Select the cancer site(s) that will be addressed during the proposed project.
Topics: Select the primary, secondary and tertiary topic(s) to be addressed by the program.
Geographic Area Served: Select the geographic area(s) where the proposed program will provide service.
Common Scientific Outline (CSO) Research Classification: Select one primary and one secondary CSO code that best describes the proposed research from the CSO Research Classification list. (See list below.)
Vertebrate Animals: Indicate if vertebrate animals will be used in the proposed work and if vertebrate animals will be used by a subcontractor. If no vertebrate animals will be used, mark the appropriate box.
Cadaver Materials Used: The term "cadaver" means a deceased person or portion thereof. The term "cadaver" includes organs, tissue, eyes, bones, arteries, blood, fluid or other portion of a deceased person. The term "cadaver" does not include portions of an individual, such as tissue or blood, that were removed from the individual for research purposes while the individual was still alive (for example, if an individual donates tissue for use in future research, that tissue is not a "cadaver", regardless of whether the individual is living or dead during subsequent use of the tissue). If no cadaver materials will be used, mark the appropriate box.
Human Anatomical Substances (not including cadaver materials): Indicate all human anatomical substances that will be used in this study. If no human anatomical substances will be used, mark the appropriate box.
Human Anatomical Substances Traceable to Donors: Indicate whether human anatomical substances can be traced to a specific donor.
Safety Provisions: Select all that apply.
Human Subjects: Indicate all human subjects that will be used in this study. If no human subjects will be used, mark the appropriate box.
For Gender, Demographics, Health Disparity, Ethnicity, Age, General Income, and U.S. Military Affiliation, indicate the appropriate descriptors for the human test subjects/study population that is being specifically targeted in the proposed research.
Data Collection from Human Subjects: Indicate all methods of all data collection on human subjects that will be used in this study. If no data collection from human subjects will be used, mark the appropriate box.
Clinical Trials: Indicate all of the types of clinical trials that are in the proposed work. If no clinical trials are proposed in this study, mark the appropriate box.
DUNS Number: The DUNS number is a unique nine digit identification number for each physical location of your business. If you are unsure of this number, please check with your Application Signing Official (ASO) at your organization or institution; he/she should be able to provide this number to you.
EIN: The EIN number is assigned by the Internal Revenue Service. If you are unsure of this number, please check with your Application Signing Official (ASO) at your organization or institution; he/she should be able to provide this number to you.
|Topic Codes List|
|0100 Cell Biology: Covers the study of the cell, its structure, including cellular organization, regulation, composition, and function on normal and transformed cells.|
|0101||Cell Cycle||Covers studies on the sequence and regulation of cellular events between mitotic divisions.|
|0102||Cellular Structure||Covers the study of proteins and other macromolecules that are involved in mediating the recognition and adhesion of cells to their substrates and to other cells to include adhesion, integrins, matrix, membrane bound proteins, and cytoskeletal components.|
|0103||Growth Factors/Cytokines||Covers studies on polypeptides and their receptors which control the ontogeny and maintenance of tissue form and function.|
|0104||Oncogenes||Covers studies on genes whose mutation or overexpression promotes tumor development/malignant phenotype.|
|0105||Tumor Suppressor Genes||Covers studies on genes whose mutation or inactivation leads to tumor development/malignant phenotype.|
|0106||Metabolism||Covers studies on the sum of all physical and chemical processes by which an organism is produced and maintained as well as the transformations by which energy is made available for use by the organism.|
|0107||Signal Transduction||Covers studies on the activation of intracellular response pathways.|
|0108||Structural Chemistry||Studies to determine the structure of biological compounds such as X-ray crystallography, nuclear magnetic resonance, and computer modeling.|
|0109||Functional Study of Biological Molecules||Studies that determine the function of newly identified biological molecules or novel functions of previously studied molecules.|
|0110||Electrophysiology||Covers studies on the electrical properties of cells.|
|0111||Cellular Development||Covers studies on the development and differentiation of cells, including embryonic and adult stem cells but excluding cancer stem cells.|
|0115||Tyrosine Kinase Signaling|
|0116||Mammary Gland Development|
|0117||Signaling: Life and Death|
|0200 Genetics and Molecular Biology: Covers studies on the molecular structures and events underlying biological processes, especially the relation between genes and the functional characteristics they determine.|
|0201||Chromosome Structure||Covers studies on the organization of the DNA into a chromosome, and the accompanying chromosomal elements and staining and sequencing techniques.|
|0202||DNA Damage and Repair||Covers studies on the mechanisms of DNA damage as well as the enzymatic correction of errors in DNA structure and sequence.|
|0203||Genomic Instability||Covers studies on genetic changes that result in new combinations of alleles and/or chromosomal modifications such as crossing over, deletions, translocations, and loss of heterozygosity.|
|0204||Familial and Hereditary Carcinogenesis||Covers studies of genes and their products which cause disease in familial or hereditary clusters.|
|0207||Genomics||The study of a set or subset of genes expressed in a cell.|
|0208||Proteomics||The study of a set or subset of proteins expressed in a cell.|
|0209||Transcription||Covers studies on the process by which RNA is copied from a DNA template. This includes modes of regulation of this process such as methylation, acetylation and phosphorylation of chromatin, microRNA, and RNA processing events.|
|0210||Translation and Modification||Covers studies on the process whereby proteins are generated from an RNA template. Also includes the regulation of translation via siRNA, RNA degradation, etc., and any post-translational events such as phosphorylation, glycosylation, etc.|
|0300 Endocrinology: Covers studies on structure and function of endocrine glands, their products, and their control to include hormones and their receptors.|
|0301||Clinical Endocrinology||Covers studies of hormonal functions, ligand interactions, and metabolism as it relates to bedside and clinical applications.|
|0302||Endocrine Pathogenesis||Covers studies on the role of hormones in the initiation and progression of disease.|
|0303||Hormone Metabolism||Covers studies of the biosynthesis, degradation, and enzymatic interconversions of hormones and structural analogs.|
|0304||Hormone Receptors||Covers studies related to membrane-bound or intracellular molecules that bind with high affinity to, or respond to, hormones.|
|0305||Mechanism of Hormone Action||Covers studies of interactions between a ligand, its receptor, and co-activators, in targeted metabolic processes, and the downstream consequences of these interactions.|
|0400 Pathobiology: Covers studies on the pathobiology of cells and tissues specifically related to the development of disease.|
|0401||Angiogenesis||Covers studies on the neo-vascularization associated with tumor growth and the factors that mediate this phenomenon.|
|0402||Apoptosis||Covers studies on the process of a particular form of a cell death, programmed cell death, that is characterized by specific morphologic and biochemical properties.|
|0403||Biomarkers||Covers studies on cellular constituents whose presence and/or concentration might serve as an indicator of the predisposition, presence or progression of disease. Includes the study of detection agents for uncharacterized biomarkers.|
|0404||Chemical/Physical Carcinogenesis||Covers studies on the influence of chemicals and other environmental factors on pathogenesis.|
|0406||Stromal-Epithelial Interactions||Covers studies on the role of the interaction of the stromal and epithelial elements in the initiation of disease.|
|0407||Invasion and Metastasis||Studies on identifying, isolating, or culturing the clonogenic, pluripotent, self-renewing progenitor cells believed to be responsible for malignancy.|
|0500 Immunology: Covers studies of the cell mediated and humoral aspects of immunity and immune responses excluding therapeutic manipulations of the immune system.|
|0502||Tumor Immunology||Covers studies of interactions between the immune system and tumor(s).|
|0503||Regulation of the Immune Response||Covers studies of mechanisms that up- or down-regulate the immune system, including psychoneuroimmunology.|
|0504||Immunodeficiency||Covers studies of inadequacies in the cell mediated or humoral aspects of immune response or its regulation.|
|0505||Autoimmunity and Autoimmune Disease||Covers studies of specific immunity to constituents of self.|
|0600 Primary Prevention: Covers studies that prevent the occurrence of disease.|
|0601||Lifestyle||Covers studies of the contributions and consequences of lifestyle and behavioral factors on disease risk, as well as studies to test educational and lifestyle interventions to reduce disease risk.|
|0602||Chemoprevention||Covers studies on the effect(s) of drugs to prevent occurrence of disease.|
|0603||Nutrition||Covers studies on the contributions and consequences of diet and/or nutrition on disease risk, as well as to test educational and diet and/or nutritional interventions intended to prevent the occurrence of disease.|
|0604||Genetic Risk||Covers studies among individuals with defined gene composition and genetic mutations to test interventions intended to prevent the occurrence of disease.|
|0605||Surgical Prevention||Covers studies on the effects of prophylactic surgical interventions to prevent occurrence of disease.|
|0606||Complementary and Alternative Medicine||Covers studies in non-traditional/alternative methods of prevention. These include a) alternative medical methods such as homeopathy, naturopathy, chiropracty, osteopathy, or acupuncture; b) mind-body techniques such as support groups, writing, and art; c) bio-energy techniques such as gi gong, Reiki, therapeutic touch and other non-traditional uses of electromagnetic fields.|
|0700 Detection and Diagnosis: Covers the study of improved detection, diagnostic and prognostic techniques. Includes studies investigating disease presence and potential response to prevention and treatment strategies.|
|0702||Cell/Tissue/Body Fluid Sampling||Covers the study of methods for collecting biological samples and studies on the most effective testing of these specimens for the detection, diagnosis, or prognosis of disease.|
|0703||Computer-Aided Diagnostics||Covers the use of computer algorithms and/or artificial intelligence to aid in making diagnostic decisions.|
|0704||Digital Imaging||Covers the study of capturing, storing, viewing, and analyzing radiographic or other images in a digital format.|
|0705||Magnetic Resonance Imaging||Covers the study of visualization of structures in the body by use of oscillating magnetic fields and analysis of the resulting radio frequencies produced.|
|0706||Nuclear Medicine Imaging||Covers the study of image production or count acquisition after the administration of a radionuclide.|
|0707||Ultrasonography||Covers the study of visualization of structures in the body by recording the reflections of high frequency sound waves directed into the tissues.|
|0708||X-Ray Imaging||Covers the study of visualization of structures in the body by externally applied ionizing radiation.|
|0710||Agent Development||Covers the discovery, screening, synthesis, development, formulation, and pharmacology of detection and diagnostic agents or modification of existing agents to include accessory or auxiliary agents.|
|0711||Spectrometry||Covers the direct measurement of electromagnetic waves, changes in mass, or changes in charge whose detection and quantification can be used for screening, diagnosis, or prognosis. This excludes visualization of structures in the body through imaging techniques.|
|0712||Nanotechnology||Covers the use of nanotechnology methods, techniques, or agents for the detection, diagnosis or prognosis of disease. Nanotechnology includes creation of structures, devices and systems whose size is approximately less than or equal to 100 nm or less.|
|0800 Clinical and Experimental Therapeutics: Covers studies on agents to assess their use in treatment. Includes model systems ranging from cell cultures to animals and humans.|
|0801||Drug Design and Development (820)||Covers the discovery, screening, synthesis, development and formulation of drugs and the modification of existing agents.|
|0802||Pharmacology||Covers studies of the pharmacokinetics, toxicity, routes of administration and mechanisms of action of treatment agents. This may include drugs that modify the effectiveness of other drugs.|
|0803||Chemotherapy||Covers the study of using drugs or a combination of drugs to kill or halt the growth of aberrant cells. This may include drugs that modify the effectiveness of other drugs.|
|0804||Drug Resistance/Multi-drug Resistance (821)||Covers the study of the mechanisms, treatments, and prevention of classical MDR and other forms of drug resistance.|
|0805||Targeted Therapies (Conjugated Toxins)||Covers the development, testing, and study of individual agents that target cells or combined agents that contain a targeting component with a toxic or therapeutic component.|
|0806||Vaccines||Covers the study of treatment of disease with agents designed to elicit immune responses to specific antigens.|
|0807||Immunotherapies||Covers the study of treatment of disease by passive immunization or by the use of agents designed to potentiate or suppress actions of leukocytes. Excludes vaccines.|
|0808||Radiotherapy||Covers the study of using ionizing radiation to treat disease or kill cells.|
|0809||Community and Clinical Partnerships|
|0810||Gene Therapy||Covers the study of treatment that modifies or inserts genes into cells to improve the body's natural ability to fight disease or to make the tumor more sensitive to other therapies. Includes gene vector development and antisense technologies.|
|0811||Photodynamic Therapy||Covers the study of light activated substances in treating disease.|
|0812||Antiangiogenics||Covers the study of using substances that inhibit blood vessel formation accompanying tumor growth.|
|0813||Surgery||Covers studies on procedures designed to remove or repair tissue cells.|
|0814||Hypo/Hyperthermia||Covers the study of localized or systemic temperature changes for either direct therapeutic effect or enhancing the effectiveness of other therapies.|
|0815||Rehabilitation||Covers the study of interventions to improve functional status and/or appearance related to disease or treatment. Examples would include prosthetic devices, plastic/reconstructive surgery, and occupational/physical/speech therapy.|
|0816||Symptom Management||Covers studies of the factors or interventions that influence disease-specific symptoms and/or reduce treatment side-effects. Symptom management may be medically or psychosocially based.|
|0817||Breast Cancer Vaccines|
|0818||Clinical Management of Breast Cancer|
|0822||Evolving Therapeutic Targets|
|0823||Hormonal Therapy and Resistance|
|0900 Complementary and Alternative Medicine: Covers studies of treatments and practices that reflect nontraditional forms of intervention or supportive methods that complement or add to mainstream treatments.|
|0901||Neutraceuticals||Covers the study of nutritional, vitamin and/or dietary supplements and herbal remedies as forms of non-traditional interventions and/or complementary treatment to traditional interventions.|
|0902||Complementary and Alternative Medicine|
|1000 Health Care Delivery: Covers studies assessing the delivery of disease prevention, detection, treatment and rehabilitation services.|
|1003||Health Care Delivery|
|1100 Biobehavioral Sciences: Covers studies describing knowledge, attitudes and behavior in defined populations and assessing the relationship(s) between behavioral and social functioning and disease initiation, progression, detection, treatment, and rehabilitation.|
|1101||Basic Behavioral||Covers descriptive studies of knowledge, attitudes and behavior in defined populations or studies of the basic relationships between biology and behavioral factors and disease.|
|1102||Quality of Life||Covers studies with specific aims or objectives to understand the factors that contribute to Quality of Life (QOL), interventions designed to enhance QOL, and/or the QOL consequences that result from actions by patients, caregivers, and/or providers among individuals with or at risk for disease.|
|1103||Decision Making||Covers studies of factors that contribute to patient, caregiver, or provider decision-making regarding diagnosis, treatment and/or rehabilitation, such as participation in clinical trials, risk assessment, genetic counseling and adherence to treatment.|
|1104||Health Communication and Education||Exploration of health communications theories and their application to disease and disease control issues, studies to fill gaps in understanding how patients, care givers, health care providers and the general population use health information and development and testing of educational interventions.|
|1105||Lifestyle||Covers studies of interventions that reduce disease risk, enhance treatment efficacy, improve prognosis and/or overall health, such as physical activity, stress reduction, supportive care, etc.|
|1200 Epidemiology: Covers population-based observational research studies of the distribution of disease as well as the behavioral and/or biological determinants of disease risk, initiation, progression, detection and/or prognosis.|
|1201||Descriptive Epidemiology and Surveillance||Covers population-based observational research studies of the distribution and characteristics of disease.|
|1202||Genetic Epidemiology||Covers population-based observational studies assessing the nature of associations between lifestyle and host factors and disease risk, initiation, progression, detection, prognosis and/or treatment.|
|1203||Environmental Epidemiology||Covers population-based observational studies assessing the nature of associations and effect modification between genetic susceptibility, polymorphic genes and environmental or host factors and disease risk, initiation, progression, and/or intermediate disease endpoints.|
|1204||Nutritional Epidemiology||Covers population-based observational studies assessing the nature of associations and effect modification between nutritional factors and disease risk, initiation, progression, detection, and prognosis.|
|1300 Research Resources: Covers support for the development and/or maintenance of institutional, regional, or national resources to sustain biomedical research.|
|1301||Training Programs||Covers support for extramural programs to train investigators.|
|1302||Research Resources and Registries||Covers support for development and maintenance of registries i.e., central agencies for the collection of pathologic material and related clinical, laboratory, x-ray, and other data in a specified field of pathology, organized so that the data can be properly processed and made available for study).|
|1303||Animal Models||Covers support for development of vertebrate and invertebrate animal models of human diseases.|
|1304||Computer Models||Covers support for the development and maintenance of computer modeling and information management systems and novel uses of information technology.|
|1305||Centers, Clinical Centers, or Consortia||Covers support for the development of core-supported, multi-project research programs integrated around a common theme.|
|1306||Statistical Models||Covers support for the development of models for data analysis.|
|1307||Cell Lines||Covers the development of immortalized cell lines.|
|1308||Survey/Instrument Development and Validation||Covers support for the design and/or validation of survey instruments that have the potential for use across research studies.|
|1309||Technology and Informatics|
|1399||Not Otherwise Specified||Covers studies in research resources not otherwise specified in the other research areas.|